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Keep an eye on Intently (one)pentobarbital will lessen the extent or influence of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to a minimize in fentanyl plasma concentrations, insufficient efficacy or, possibly, gro